New incompatible pair of TCM: Epimedii Folium combined with Psoraleae Fructus induces idiosyncratic hepatotoxicity

Yuan Gao, Zhilei Wang, Jinfa Tang, Xiaoyi Liu, Wei Shi, Nan Qin, Xiaoyan Wang, Yu Pang, Ruisheng Li, Yaming Zhang, Jiabo Wang, Ming Niu, Zhaofang Bai, Xiaohe Xiao

Frontiers of Medicine 2020, Volume 14, Issue 1,   Pages 68-80 doi: 10.1007/s11684-019-0690-z

Keywords： Epimedii Folium     Psoraleae Fructus     idiosyncratic hepatotoxicity     traditional Chinese medicine incompatibility    

Bavachin enhances NLRP3 inflammasome activation induced by ATP or nigericin and causes idiosyncratic hepatotoxicity

Nan Qin, Guang Xu, Yan Wang, Xiaoyan Zhan, Yuan Gao, Zhilei Wang, Shubin Fu, Wei Shi, Xiaorong Hou, Chunyu Wang, Ruisheng Li, Yan Liu, Jiabo Wang, Haiping Zhao, Xiaohe Xiao, Zhaofang Bai

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 594-607 doi: 10.1007/s11684-020-0809-2

Keywords： Psoraleae Fructus     bavachin     idiosyncratic drug-induced liver injury     caspase-1     IL-1β     NLRP3 inflammasome